WEIGHT-LESS: NO. 4 SYSTEMIC BOOSTER

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WEIGHT-LESS: NO. 4 SYSTEMIC BOOSTER

59.94

A Smart Formula for Less Weight and More Energy


Weight Less is a smart formula that healthily promotes weight loss and sustained energy levels throughout the day.*
A powerful mix of wild crafted brown seaweed extracts of Ascophyllum nodosum (kelp) and Fucus vesiculosus (bladderwrack) are shown in research to manage weight reduction and support metabolic health. Moreover, wild brown seaweeds are found to contain potent marine anti-inflammatory and antioxidant factors. Together with 7-Keto DHEA, the mix turns on fat burning mechanism, lowers the glycemic level of meals, and supports sustained energy. Take 1-2 capsules a half hour before meals.*


Weight-Less is Wild Crafted (seaweeds), Organic (seaweeds), Vegan, Kosher, Non GMO, and Gluten Free.


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Weight-Less is a smart formula for less weight and more energy. Comprised of wild-crafted brown seaweed, Ascophyllum nodosum (kelp) and Fucus vesiculosus (bladderwrack), along with 7-Keto DHEA, Weight-Less is unique and effective.*

Marine algae, in particular, wild brown seaweed such as kelp and bladderwrack are shown to lower the glycemic load of complex and simple carbohydrates for better insulin management, as well as offer a power-filled phenolic activity for antioxidant and anti-inflammation effect (Roy et al., 2011). 7-Keto has been used for many years to turn on fat burning mechanism and offer an effective and safe way to lose weight (Bobyleva et al., 1997). Together, Weight-Less promotes a sustained energy level throughout the day as it modulates carbohydrate digestion and absorption for better weight management and metabolic health ( Gabbia et al., 2017; Catarino et al., 2017).*

Weight management is essential to our health, yet difficult to achieve. Research has correlated excess body fat with metabolic syndrome, which includes high blood sugar, high blood pressure, high cholesterol and triglycerides. These metabolic syndrome factors are found to increase the risk for cardiovascular issues, obesity, diabetes, and cancer (American Heart Association, 2017; National Cancer Institute, 2017). In fact, metabolic syndrome is now a growing public health concern worldwide (Wright et al., 2017; Calton et al., 2014).*

Inflammation is also shown in research to link obesity and cardio–metabolic risks for obese and non-obese individuals (Phillips & Perry, 2013). Hence, a diet of whole plants rich in phenols is shown in research to offer anti-inflammatory benefits (Wright et al., 2017; McAnulty et al., 2014). Weight-Less is comprised of wildcrafted brown seaweeds shown in research to offer potent phenols with high total antioxidant potency, antidiabetic properties, and anti-inflammatory potential (Gabbia et al., 2017; Catarino et al., 2017; Pantidos et al., 2014; Bahar et al., 2012).*

Studies have linked low glycemic index to improved cardiovascular health, blood sugar control, weight control, and even skin health (McMillan-Price et al., 2006, Barclay et al., 2008, Hare-Bruun et al., 2006; Smith et al., 2007, respectively). For this reason, 250 mg of brown seaweed extracts of kelp and bladderwrack is used half an hour before meals to aid carbohydrate digestion and assimilation; shifting high glycemic index food to one typical of a low glycemic index food (Paradis et al., 2011; Roy et al., 2011; Bérubé et al., 2014). Studies find supplementing with brown seaweed before meals to help slow down the digestion of whole or simple carbs to significantly reduce blood glucose for overall glycemic control (Gabbia et al., 2017; Bérubé et al., 2014; Kim et al., 2014; Lamarche et al., 2010). Glycemic control supports a consistent metabolic health and weight management.*

7-Keto DHEA, or 7-oxo DHEA is named after the compound 3-acetyl-7-oxo dehydroepiandrosterone, a substance found naturally in the body that is metabolized from the hormone DHEA (Marwah et al., 2002). Studies have indicated that 7-Keto is stable (does not convert to testosterone or estrogens), safe and effective as part of a weight loss program (Lardy et al., 1995, Davidson et al., 2000; Humanetics Corps, 2005, respectively). In fact, 7-Keto has shown in studies to activate 3 thermogenic enzymes, known to help the body convert stored fat to energy (Zenk et al., 2007, 2004). But since levels of DHEA and 7-oxo decline in our body with age, supplementation with 7-Keto helps maintain healthy levels for weight management (Lardy et al., 1998; 1995).*

In the pre-clinical development (see Bobyleva et al., 1993), 7-Keto was found to behave similarly to the thyroid hormone which also activates the thermogenic enzymes in our body. 7-oxo DHEA showed similar ability to restore mitochondrial function (Bobyleva et al., 1997) and support weight loss by enhancing thermogenic enzyme activity.*

Clinical trials have been ongoing since 1999, in specific, two randomized, double-blinded, placebo-controlled (“RDBPC”) in 1999 and 2000 have shown that 7-keto significantly increased weight loss over a period of eight weeks compared to the placebo group (Zenk et al., 2002; see also Kaiman et al., 2000; Bobyleva et al., 1997).*

Thermogenesis is the creation of heat in the body; a form of energy that is produced when we eat and metabolize food. Kaiman et al. (2000; see also Zenk et al., 2002) conducted a RDBPC study of 30 healthy overweight adults for 8 weeks. The group taking the supplement of 7-Keto showed a significantly reduced body weight. The study included exercise (three times a week) and a reduced caloric diet for both placebo and 7-Keto groups. Zenk et al. (2004; 2007) similarly found that 7-Keto increased metabolism, which is shown in research to promote weight lose and support the management of weight overall. By up-regulating the activity of fat burning enzymes (the thermogenic effect), energy expenditure is increased, enhancing the process of weight loss (Gomez et al., 2002).*

Moreover, 7-xox DHEA is also shown in research to enhance memory in young and old rats (Shi et al., 2000), immune modulation in older men (Hampl et al., 2000), and significantly enhance depressive symptoms and hypo-immunity of mice when induced by chronic mild stress (Liu et al., 2003).*

What is an ideal diet for weight loss and good health? Research studies link the emerging global pattern of metabolic syndrome and weight gain to the prevalence of Westernized diet: the daily consumption of meats, dairy, eggs, simple and processed carbohydrates, and too much sugar (Chai et al., 2017; Azadbakht & Esmaillzadeh, 2009; Lutsey et al., 2008). Although there are conflicting views on dietary guidelines, many scientists and health organizations have come to the conclusion that a focus on whole food, plant-based diet is the healthiest guideline for metabolic syndrome and weight loss (Yokoyama et al., 2017; Satija et al., 2017; Kahleova et al., 2017; Hever et al., 2017; Turner et al., 2017; UN Report, 2016; Wang et al., 2015; Tilman & Clark, 2014; WHO/FAO, 2003).*

In fact, low carbohydrate diets with high fat content is shown to increase metabolic syndrome (Lamont et al., 2017; UN Report, 2016). Hence, the type and nature of carbohydrates we chose for our diet is important. To improve our metabolic health (and guard against obesity, cardiovascular, and diabetes), our carbohydrates should be comprised of whole plants with fiber (Wright et al., 2017).*

The Plates, Pyramids, Planet report, compiled in collaboration with the Food Climate Research Network (FCRN) at the University of Oxford, concludes that a plant-based diet has many advantages for our health, the environment, and our planet (UN Report, 2016). Many organizations teach and support the transition into a whole food, plant-based diet.*

Weight-Less offers a unique combination of wild brown seaweed extracts of kelp and bladderwrack with 7-Keto DHEA. The formula is potent with antioxidants, smartly supports weight loss and management, enhances the body’s ability to burn fat more efficiently, creates energy, and promotes metabolic health. Together with a focus on whole food plant-based diet and a reasonable exercise program, managing weight becomes effective, healthy, and even joyful. *

REFERENCES

American Heart Association. (2017). About metabolic syndrome. Article

Amine, E., Baba, N., Belhadj, M., Deurenbery-Yap, M., Djazayery, A., Forrester, T., ... & Katan, M. (2002). Diet, nutrition and the prevention of chronic diseases: report of a Joint WHO/FAO Expert Consultation . World Health Organization. Diet, nutrition and the prevention of chronic diseases - World Health ...

Azadbakht, L., & Esmaillzadeh, A. (2009). Red meat intake is associated with metabolic syndrome and the plasma C-reactive protein concentration in women. The Journal of nutrition139(2), 335-339. DOI: 10.3945/jn.108.096297

Barclay, A. W., Petocz, P., McMillan-Price, J., Flood, V. M., Prvan, T., Mitchell, P., & Brand-Miller, J. C. (2008). Glycemic index, glycemic load, and chronic disease risk—a meta-analysis of observational studies. The American journal of clinical nutrition87(3), 627-637. Abstract

Bahar, B., O’Doherty, J. V., Hayes, M., & Sweeney, T. (2012). Extracts of brown seaweeds can attenuate the bacterial lipopolysaccharide-induced pro-inflammatory response in the porcine colon ex vivo. Journal of animal science90(Supplement_4), 46-48. Abstract

Bobyleva, V., Bellei, M., Kneer, N., & Lardy, H. (1997). The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Archives of biochemistry and biophysics341(1), 122-128.https://doi.org/10.1006/abbi.1997.9955

Calton, Emily K., Anthony P. James, Poonam K. Pannu, and Mario J. Soares. "Certain dietary patterns are beneficial for the metabolic syndrome: reviewing the evidence." Nutrition Research 34, no. 7 (2014): 559-568. DOI: 10.1016/j.nutres.2014.06.012

Catarino, M. D., Silva, A., & Cardoso, S. M. (2017). Fucaceae: A source of bioactive phlorotannins. International journal of molecular sciences18(6), 1327. Article

Chai, W., Morimoto, Y., Cooney, R. V., Franke, A. A., Shvetsov, Y. B., Le Marchand, L., ... & Maskarinec, G. (2017). Dietary Red and Processed Meat Intake and Markers of Adiposity and Inflammation: The Multiethnic Cohort Study. Journal of the American College of Nutrition36(5), 378-385. DOI: 10.1080/07315724.2017.1318317

Davidson, M., Marwah, A., Sawchuk, R. J., & Maki, K. (2000). Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clinical and investigative medicine23(5), 300. Abstract

Gabbia, D., Dall’Acqua, S., Di Gangi, I. M., Bogialli, S., Caputi, V., Albertoni, L., ... & De Martin, S. (2017). The Phytocomplex from Fucus vesiculosus and Ascophyllum nodosum Controls Postprandial Plasma Glucose Levels: An In Vitro and In Vivo Study in a Mouse Model of NASH. Marine drugs15(2), 41. DOI: 10.3390/md15020041

Gonzalez Fischer, C., & Garnett, T. (2016). Plates, pyramids, planet. Oxford, UK: Oxford University. Abstract

Gomez, F. E., Miyazaki, M., Kim, Y. C., Marwah, P., Lardy, H. A., Ntambi, J. M., & Fox, B. G. (2002). Molecular differences caused by differentiation of 3T3-L1 preadipocytes in the presence of either dehydroepiandrosterone (DHEA) or 7-oxo-DHEA. Biochemistry,41(17), 5473-5482. Abstract

Hare-Bruun, H., Flint, A., & Heitmann, B. L. (2006). Glycemic index and glycemic load in relation to changes in body weight, body fat distribution, and body composition in adult Danes. The American journal of clinical nutrition84(4), 871-879. Abstract

Hampl, R., Lapcik, O., Hill, M., Klak, J., Kasal, A., Novacek, A., ... & Starka, L. (2000). 7-Hydroxydehydroepiandrosterone-a natural antiglucocorticoid and a candidate for steroid replacement therapy? Physiological Research49, S107-S112. Article

Hever, J., & Cronise, R. J. (2017). Plant-based nutrition for healthcare professionals: implementing diet as a primary modality in the prevention and treatment of chronic disease. Journal of Geriatric Cardiology: JGC14(5), 355. DOI: 10.11909/j.issn.1671-5411.2017.05.012

Humanetics Corporation (2005). 7 Keto Innovative Weight Loss. Retrieved from www.humaneticscorp.com.

Kahleova, H., Levin, S., & Barnard, N. (2017). Cardio-Metabolic Benefits of Plant-Based Diets. Nutrients9(8), 848. DOI: 10.3390/nu9080848

Kaiman, D. S., Colker, C. M., Swain, M. A., Torina, G. C., & Shi, Q. (2000). A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Current therapeutic research61(7), 435-442. https://doi.org/10.1016/S0011-393X(00)80026-0

Kim, K. T., Rioux, L. E., & Turgeon, S. L. (2014). Alpha-amylase and alpha-glucosidase inhibition is differentially modulated by fucoidan obtained from Fucus vesiculosus and Ascophyllum nodosum. Phytochemistry98, 27-33. https://doi.org/10.1016/j.phytochem.2013.12.003

Lamarche, B., Paradis, M. È., & Couture, P. (2010). Study of the acute impact of polyphenols from brown seaweeds on glucose control in healthy men and women. The FASEB Journal24(1 Supplement), 209-4. Abstract

Lamont, B. J., Waters, M. F., & Andrikopoulos, S. (2016). A low-carbohydrate high-fat diet increases weight gain and does not improve glucose tolerance, insulin secretion or β-cell mass in NZO mice. Nutrition & diabetes6(2), e194. DOI: 10.1038/nutd.2016.2

Lardy, H., Partridge, B., Kneer, N., & Wei, Y. (1995). Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. Proceedings of the National Academy of Sciences92(14), 6617-6619. Abstract

Lardy, H., Kneer, N., Wei, Y., Partridge, B., & Marwah, P. (1998). Ergosteroids II: biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids63(3), 158-165. https://doi.org/10.1016/S0039-128X(97)00159-1

Liu, Y. Y., Yang, N., Kong, L. N., & Zuo, P. P. (2003). Effects of 7-oxo-DHEA treatment on the immunoreactivity of BALB/c mice subjected to chronic mild stress. Yao xue xue bao= Acta pharmaceutica Sinica,38(12), 881-884. Abstract

Lutsey, P. L., Steffen, L. M., & Stevens, J. (2008). Dietary intake and the development of the metabolic syndrome. The Atherosclerosis risk in communities study. Circulation117(6), 754-761. DOI: 10.1161/CIRCULATIONAHA.107.716159

Marwah, A., Marwah, P., & Lardy, H. (2002). Ergosteroids: VI. Metabolism of dehydroepiandrosterone by rat liver in vitro: a liquid chromatographic–mass spectrometric study. Journal of Chromatography B767(2), 285-299. https://doi.org/10.1016/S1570-0232(01)00570-0

McAnulty, L.S., Collier, S.R., Landram, M.J., Whittaker, D.S., Isaacs, S.E., Klemka, J.M… McAnulty, S.R. (2014). Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females. Nutr Res, 34 (7), 577-84. DOI: 10.1016/j.nutres.2014.07.002

McMillan-Price, J., Petocz, P., Atkinson, F., O’Neill, K., Samman, S., Steinbeck, K., ... & Brand-Miller, J. (2006). Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial. Archives of internal medicine166(14), 1466-1475. Article

Pantidos, N., Boath, A., Lund, V., Conner, S., & McDougall, G. J. (2014). Phenolic-rich extracts from the edible seaweed, ascophyllum nodosum, inhibit α-amylase and α-glucosidase: Potential anti-hyperglycemic effects. Journal of Functional Foods10, 201-209.https://doi.org/10.1016/j.jff.2014.06.018

Paradis, M. E., Couture, P., & Lamarche, B. (2011). A randomised crossover placebo-controlled trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and insulin levels in men and women. Applied Physiology, Nutrition, and Metabolism36(6), 913-919. DOI:10.1139/h11-115

Phillips, C. M., & Perry, I. J. (2013). Does inflammation determine metabolic health status in obese and nonobese adults? The Journal of Clinical Endocrinology & Metabolism98(10), E1610-E1619. https://doi.org/10.1210/jc.2013-2038

Roy, M. C., Anguenot, R., Fillion, C., Beaulieu, M., Bérubé, J., & Richard, D. (2011). Effect of a commercially-available algal phlorotannins extract on digestive enzymes and carbohydrate absorption in vivo. Food research international44(9), 3026-3029.https://doi.org/10.1016/j.foodres.2011.07.023

Satija, A., Bhupathiraju, S. N., Spiegelman, D., Chiuve, S. E., Manson, J. E., Willett, W., ... & Hu, F. B. (2017). Healthful and unhealthful plant-based diets and the risk of coronary heart disease in US adults. Journal of the American College of Cardiology70(4), 411-422.https://doi.org/10.1016/j.jacc.2017.05.047

Shi, J., Schulze, S., & Lardy, H. A. (2000). The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice. Steroids65(3), 124-129. https://doi.org/10.1016/S0039-128X(99)00094-X

Smith, R. N., Mann, N. J., Braue, A., Mäkeläinen, H., & Varigos, G. A. (2007). A low-glycemic-load diet improves symptoms in acne vulgaris patients: a randomized controlled trial. The American journal of clinical nutrition86(1), 107-115. Abstract

Šulcová, J., Hill, M., Mašek, Z., Češka, R., Nováček, A., Hampl, R., & Starka, L. (2001). Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men. Physiol Res50, 9-18. Article

Tilman, D., & Clark, M. (2014). Global diets link environmental sustainability and human health. Nature515(7528), 518-522. Article

Turner, K. M., Keogh, J. B., Meikle, P. J., & Clifton, P. M. (2017). Changes in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks. Nutrients9(8). DOI: 10.3390/nu9080886

United Nation News Centre. (2016). UN study urges governments to develop guidelines that promote ‘win-win’ diets. Article

Wang, F., Zheng, J., Yang, B., Jiang, J., Fu, Y., & Li, D. (2015). Effects of vegetarian diets on blood lipids: a systematic review and meta‐analysis of randomized controlled trials. Journal of the American Heart Association4(10), e002408. DOI: 10.1161/JAHA.115.002408

Wright, N., Wilson, L., Smith, M., Duncan, B., & McHugh, P. (2017). The BROAD study: A randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes. Nutrition & diabetes7(3), e256. DOI: 10.1038/nutd.2017.3

Yokoyama, Y., Levin, S. M., & Barnard, N. D. (2017). Association between plant-based diets and plasma lipids: a systematic review and meta-analysis. Nutrition Reviews75(9), 683-698. https://doi.org/10.1093/nutrit/nux030

Zenk, J. L., Helmer, T. R., Kassen, L. J., & Kuskowski, M. A. (2002). The effect of 7-Keto Naturalean™ on weight loss: A randomized, double-blind, placebo-controlled trial. Current therapeutic research63(4), 263-272. https://doi.org/10.1016/S0011-393X(02)80031-5

Zenk, J. L., Helmer, T. R., & Kuskowski, M. A. (2004, March). The use of 3-acetyl-7-oxo-dehydroepiandrosterone for augmenting immune response in the elderly. In FASEB JOURNAL (Vol. 18, No. 5, pp. A794-A794). 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA: FEDERATION AMER SOC EXP BIOL.

Zenk, J. L., Frestedt, J. L., & Kuskowski, M. A. (2007). HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. The Journal of nutritional biochemistry , 18(9), 629-634. https://doi.org/10.1016/j.jnutbio.2006.11.008